WIN reduced IL1β-induced inflammatory gene expression in astrocytes in a dose-dependent manner. Fold-change of IL6 (A) or C3 (B) mRNA levels normalized to ACTB mRNA levels in total RNA isolated from human astrocytes. One-way ANOVA was conducted for the effect of treatment on IL6 [F (9, 10)=24.83, p<0.0001] and C3 [F (9, 10)=107.3, p<0.0001]. A post hoc Tukey's test was conducted; corrected p-values are shown (***p<0.001; ****p<0.0001 vs. vehicle; ^^p<0.01, ^^^p<0.001, ^^^^p<0.0001 vs. IL1β-treated cells). ANOVA, analysis of variance.