Table 3.
Multivariate Analysis of Prognostic Factors in Adult Medulloblastoma
| Prognostic factors | PFS |
OS |
||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | p | Hazard ratio | 95% CI | p | |
| Metastasis at presentation | ||||||
| No Yes (Ref.) |
0.76 | 0.35–1.60 | 0.47 | 0.97 | 0.44–2.17 | 0.95 |
| Extent of resection | ||||||
| GTR/NTR STR (Ref.) |
0.97 | 0.44–2.14 | 0.93 | 0.89 | 0.39–2.04 | 0.79 |
| Risk stratification | ||||||
| SR HR (Ref.) |
0.19 | 0.06–0.55 | 0.002 | 0.17 | 0.05–0.56 | 0.004 |
| Histological subtype | ||||||
| Non-LCA LCA (Ref.) |
0.47 | 0.23–0.93 | 0.03 | 0.38 | 0.18–0.78 | 0.009 |
| Molecular subgrouping | ||||||
| WNT SHH Othersa (Ref.) |
0.15 0.63 |
0.01–1.23 0.30–1.33 |
0.07 0.22 |
0.29 0.73 |
0.04–2.38 0.32–1.67 |
0.25 0.46 |
| Interval between surgery and RT | ||||||
| >6 Weeks ≤6 Weeks (Ref.) |
1.34 | 0.70–2.56 | 0.38 | 1.2 | 0.61–2.39 | 0.59 |
All p values ≤0.05 are considered statistically significant and highlighted in bold.
a
Others pertains to non-WNT/non-SHH molecular subgroup and was used as reference.
CI, confidence interval; HR, high-risk; Ref., reference.