Fig. 5. The physicochemical parameters of simple xanthone derivatives. a–f, Molecular weight, rotatable bonds, polar surface area, hydrogen bond donors, hydrogen bond acceptors, and lipophilicity of the simple xanthones, respectively. The small molecules in light gray (17 compounds) and the combinations in dark gray (18 compounds) are anti-infective agents approved by FDA from 2015 until June 2020. Among them, the small molecules contain cresemba, dakllnza, baxdela, xepi, benznidazole, solosec, prevymis, aemcolo, xerava, krintafel, moxidectin, zemdri, nuzyra, tpoxx, xofluza, pifeltro, fetroja, xenleta, egaten, pretomanid, artesunate, and the combinations contain elvitegravir, cobicistat, emtricitabine, tenofovir alafenanids, ceftazidime, avibactam, bictegravir, meropenem, velpatasvir, vaborbactam, sofosbuvir, elbasvir, pibrentasvir, glecaprevir, grazoprevir, voxilaprevir, lmipenem, relebactam, cilastatin.³⁷.