Table 2. Relative Risk of Cancer Recurrence or Death From Any Cause (Disease-Free Survival) and Overall Mortality Among 1011 Patients With Stage III Colon Cancer, by Postdiagnostic Intake of Unprocessed Red Meat and Processed Meats.

Type of meat and event	Quartile of intake				P for trenda
	1	2	3	4
Unprocessed red meat, median (IQR), No. of servings/wk	1.5 (1.1-1.8)	2.6 (2.3-2.9)	4.0 (3.5-4.6)	6.9 (6.0-8.3)	NA
Recurrence or death
Events, No.	114	101	93	78	NA
Model, HR (95% CI)
1b	1 [Reference]	0.83 (0.63-1.08)	0.72 (0.54-0.96)	0.58 (0.42-0.80)	.001
2c	1 [Reference]	0.82 (0.62-1.09)	0.70 (0.52-0.94)	0.53 (0.38-0.75)	<.001
3d	1 [Reference]	0.97 (0.73-1.29)	0.92 (0.67-1.26)	0.84 (0.58-1.23)	.33
Overall mortality
Events, No.	96	77	72	60	NA
Model, HR (95% CI)
1b	1 [Reference]	0.75 (0.55-1.01)	0.66 (0.48-0.90)	0.54 (0.38-0.77)	.001
2c	1 [Reference]	0.76 (0.56-1.05)	0.63 (0.46-0.88)	0.48 (0.33-0.70)	<.001
3d	1 [Reference]	0.88 (0.63-1.21)	0.80 (0.57-1.13)	0.71 (0.47-1.07)	.11
Processed meat, median (IQR), No. of servings/wk	0.7 (0.4-0.9)	1.5 (1.3-1.7)	2.7 (2.3-3.2)	5.2 (4.5-6.9)	NA
Recurrence or death
Events, No.	95	104	94	93	NA
Model, HR (95% CI)
1b	1 [Reference]	1.09 (0.82-1.44)	0.90 (0.67-1.20)	0.95 (0.70-1.29)	.51
2c	1 [Reference]	1.03 (0.77-1.37)	0.81 (0.60-1.10)	0.82 (0.59-1.14)	.15
3d	1 [Reference]	1.14 (0.85-1.53)	0.96 (0.70-1.30)	1.05 (0.75-1.47)	.94
Overall mortality
Events, No.	78	79	72	76	NA
Model, HR (95% CI)
1b	1 [Reference]	1.02 (0.74-1.39)	0.85 (0.61-1.18)	0.93 (0.66-1.31)	.58
2c	1 [Reference]	0.97 (0.70-1.34)	0.78 (0.56-1.10)	0.82 (0.57-1.17)	.24
3d	1 [Reference]	1.07 (0.77-1.48)	0.90 (0.63-1.27)	1.04 (0.72-1.51)	.95

Abbreviations: HR, hazard ratio; NA, not applicable.

^a P for trend was calculated by modeling the median of each category as a continuous term.

^b Cox proportional hazards regression model was adjusted for age (years), sex (male vs female), race (Black, White, or other [ie, Hispanic, Asian, Native Hawaiian, Native American, Indian, other, or multiple race]), and energy intake (kilocalories per day). Three individuals with unknown race were categorized as other race.

^c Cox proportional hazards regression model was adjusted for variables in model 1 plus T stage (T1-T2, T3-T4, or missing), number of positive lymph nodes (1-3, ≥4, or missing), baseline performance status (0, 1-2, missing), treatment group (fluorouracil plus leucovorin vs irinotecan, fluorouracil, and leucovorin), body mass index (weight in kilograms divided by height in meters squared), physical activity (metabolic equivalent task hours per week), smoking (never, current, past, or missing), aspirin use (yes vs no), alcohol (grams per day), dark meat fish (yes vs no), vitamin D (International Units per day), cereal fiber (grams per day), high-fat dairy (servings per day), and eggs (servings per day).

^d Cox proportional hazards regression model was adjusted for variables in model 2 plus carbohydrates (grams per day).