TABLE 1.

Examples of hypotheses proposed for AD.

AD hypothesis	References
Amyloid cascade hypothesis	Hardy and Higgins, 1992, Selkoe and Hardy, 2016
Tau hypothesis	Iqbal and Grundke-Iqbal, 1996, Iqbal et al., 2016
Cholinergic hypothesis	Perry et al., 1977, Bartus et al., 1982
Mitochondrial hypothesis	Moreira et al., 2010, Swerdlow et al., 2010
Oxidative stress hypothesis	Coyle and Puttfarcken, 1993, Zhu et al., 2004
Neuroinflammation hypothesis	McGeer et al., 1994
Brain insulin resistance hypothesis	de la Monte, 2009, Deng et al., 2009
Metabolic hypothesis	Hoyer, 2000, Iqbal and Grundke-Iqbal, 2005, Gong et al., 2016
Calcium hypothesis	Khachaturian, 1994
Innate immunity hypothesis	Guillot-Sestier et al., 2015