Analysis of simulated leaflet kinematics for valves with different diameters at physiological Reynolds numbers with consistent operating and flow conditions. A though E, frequency analyses of leaflet fluttering obtained using a glycerin-based blood analog. Blue solid lines represent the simulation results obtained for a fixed operating condition but varying flow conditions (quantified by Reynolds number [Repeak]). Red dashed lines represent results in which the driving condition is modified to match Repeak. The dominant fluttering frequencies for different Reynolds number cases are: A, 59.70 and 47.86 Hz; B, 46.75 and 35.82 Hz; C, 32.00 and 31.75 Hz; D, 25.32 and 25.24 Hz; and E, 12.12 Hz. Smaller-diameter valves show higher frequency leaflet fluttering.