Table 7.
MMACA assay Diagnostic Sensitivity (DSN) and Specificity (DSP).
| Proc Logistic Model | Antigen | Antigen concentration (IU or AU/ mL)/Probability cutoff (%) | DSN | DSP |
|---|---|---|---|---|
|
| ||||
| Single analyte | Pt | 17.10 | 85.42% | 81.69% |
| 22.35 | 83.33% | 84.51% | ||
| 37.41 | 79.17% | 95.78% | ||
| 53.20 | 77.08% | 97.18% | ||
|
| ||||
| Forward Selection | Fim2/3, Pt and Pt × Fim2/3 | 36.40% | 87.50% | 85.92% |
| 38.36% | 85.42% | 88.73% | ||
| 43.62% | 83.33% | 91.55% | ||
| 49.37% | 81.25% | 94.37% | ||
|
| ||||
| Forward Selection without Hierarchy | Fha, Act × Fha, Fim2/3, Fha × Pt and Act × Prn*Pt | 19.51% | 93.75% | 78.87% |
| 21.43% | 91.67% | 78.87% | ||
| 31.38% | 87.50% | 85.92% | ||
| 35.60% | 85.42% | 87.32% | ||
|
| ||||
| Stepwise Selection without Hierarchy | Fha, Fim2/3 and Fha × Pt | 25.69% | 89.58% | 81.69% |
| 27.00% | 87.50% | 83.10% | ||
| 35.22% | 85.42% | 91.55% | ||
| 38.85% | 83.33% | 91.55% | ||
| 57.81% | 77.08% | 98.59% | ||
|
| ||||
| Backwards Selection | Act, Fha, Fim2/3, Act × Fim2/3, Fha × Fim2/3, Prn, Act × Prn, Fim2/3 × Prn, Act × Fim2/3,*Prn, Pt, Act × Pt, Fha × Pt, Fim2/3 × Pt, and Act × Fim2/3 × Pt | 9.76% | 95.83% | 77.46% |
| 14.52% | 93.75% | 85.92% | ||
| 50.23% | 91.67% | 95.77% | ||
| 55.67% | 89.58% | 97.18% | ||
| 64.05% | 87.50% | 100.00% | ||
|
| ||||
| Backwards Selection without Hierarchy | Fha, Act × Fha*Fim2/3, Prn, Act × Prn, Fha × Prn, Act × Fha*Fim2/3 × Prn, Pt, Act × PT, Fim2/3 × Pt and Act × Fha*Fim2/3 × Prn*PT | 13.33% | 95.83% | 81.69% |
| 21.50% | 93.75% | 84.51% | ||
| 50.29% | 91.67% | 95.77% | ||
| 54.51% | 87.50% | 98.59% | ||
| 63.07% | 83.33% | 100.00% | ||
Act – Adenylate cyclase; Fha – filamentous hemagglutinin; Fim2/3 - Fimbria; Prn – Pertactin; Pt – Pertussis toxin antigens.