Table III.
Univariate and multivariate analysis of different prognostic variables influencing disease-specific survival (DSS) of the HCC patients.
| Univariate analysis | Multivariate analysis model | ||||
|---|---|---|---|---|---|
|
|
|
||||
| Variable | n | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (years) | 0.304 (0.365-1.203) | 0.630 | |||
| <50 | 40 | ||||
| ≥50 | 33 | ||||
| Sex | 0.348 (0.340-1.178) | 0.405 | |||
| Male | 34 | ||||
| Female | 39 | ||||
| AFP (ng/ml) | 0.842 (0.634-1.778) | 0.836 | |||
| ≤20 | 25 | ||||
| >20 | 48 | ||||
| HBsAg | 1.135 (0.782-1.842) | 0.641 | |||
| Positive | 44 | ||||
| Negative | 29 | ||||
| TNM stage | 1.004 (0.447-1.236) | 0.009 | 1.047 (0.486-1.445) | 0.007 | |
| I/II | 29 | ||||
| III/IV | 44 | ||||
| Tumor size (cm) | 1.148 (0.556-2.014) | 0.024 | 1.214 (0.336-2.174) | 0.021 | |
| ≤5 | 36 | ||||
| >5 | 57 | ||||
| Intrahepatic metastasis | 1.047 (0.660-1.930) | 0.475 | |||
| Presence | 36 | ||||
| Absence | 37 | ||||
| JPH3 expression | 1.410 (0.559-2.014) | 0.015 | 1.507 (0.663-2.474) | 0.019 | |
| Low | 52 | ||||
| High | 21 | ||||
HR, hazard ratio; CI, confidence interval; HCC, hepatocellular carcinoma; AFP, α-fetoprotein; HBsAg, hepatitis B surface antigen; JPH3, junctophilin 3.