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. 2022 Feb 3;10:826688. doi: 10.3389/fcell.2022.826688

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Copyright © 2022 Paul, Weeratunga, Tillu, Hariri, Henne and Collins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The PXA and PXC domains combine to form an intertwined α-helical structure. (A) Structure of the PXA and PXC domains of human SNX13 predicted by AlphaFold2 in green and orange respectively, shown with cylinders for α-helices. The two domains are predicted to be tightly interwoven. (B) An overlay of the core PXA-PXC domains of human, yeast and fly SNX-RGS proteins shows that all predicted structures have the same topology. (C) Predicted structure of S. cerevisiae Nvj3 with the regions expected to be similar to PXA and PXC domains coloured green and orange and the linker shown in grey.