Table 2.

Animal models used frequently to study liver-associated metabolic disorders

Animal model	Corresponding human disease	Reference
Fumarylacetoacetate hydrolase–/– knockout mouse	Tyrosinemia type I	140
mdr2 mouse	Progressive familial intrahepatic cholestasis type 3	156
spf-ash mouse	Congenital ornithine transcarbamylase deficiency	157
Long Evans Cinnamon rat	Wilson disease	158
Gunn rat	Crigler–Najjar syndrome type I	159
Watanabe heritable hyperlipidemic rabbit	Model for low-density lipoprotein receptor deficiency	160
Hyperuricemic Dalmatian dog	Hepatocyte transplantation for hyperuricemia disorders	161