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. 2021 Aug 3;106(12):3455–3463. doi: 10.1210/clinem/dgab575

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Electrochemiluminescence (ECL)–zinc transporter 8 autoantibody (ZnT8A) and radiobinding assay (RBA)-ZnT8A in the Autoimmunity Screening for Kids study. A, Comparison of cumulative incidence (%) of clinical type 1 diabetes (T1D) (stage 3 T1D) in 2 groups: RBA + ECL + and RBA + ECL–. Solid line: individuals with RBA-ZnT8A confirmed by ECL, dotted line: individuals with RBA-ZnT8A not confirmed by ECL. B, Positive predictive values (PPV) of stage 1 to stage 3 T1D in individuals with ECL-ZnT8A or RBA-ZnT8A.