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. 2021 Aug 3;106(12):3455–3463. doi: 10.1210/clinem/dgab575

Table 2.

Demographic data of children from the Autoimmunity Screening for Kids study with zinc transporter 8 autoantibody

Group RBA + ECL+ RBA + ECL– P
No. 70 65
Age at screening, y 8.7 ± 4.0 9.7 ± 4.5 .21
Male sex, % 54.3 49.2 .61
Family history of T1D, % 25.7 15.4 .14
RBA-ZnT8 RBA levels, DK units
 Median 0.150 0.055 < .001
 IQR 0.071 ~ 0.420 0.042 ~ 0.095
Multiple IAbs positive, % 85.9 (61/70) 15.6 (10/65) < .001
GADA positivity, No. (%) 51 (72.9) 4 (6.2) < .001
IAA positivity, No. (%) 42 (60.0) 3 (4.6) < .001
IA-2A positivity, No. (%) 45 (64.3) 8 (12.3) < .001
Clinical T1D at follow-up, No. 16 1 < .001

Abbreviations: ASK, Autoimmunity Screening for Kids; ECL, electrochemiluminescence; GADA, glutamic acid decarboxylase; IAA, insulin autoantibodies; IA-2A, insulinoma-associated protein 2; IAbs, islet antibodies; IQR, interquartile range; RBA, radiobinding assay; T1D, type 1 diabetes.