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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Br J Dermatol. 2021 Aug 13;185(5):999–1012. doi: 10.1111/bjd.20519

Figure 2.

Figure 2

MicroRNA profile of cutaneous T-cell lymphoma (CTCL) cell-line-derived exosomes and delivery of highly expressed exosomal microRNAs. (a) Hierarchical clustering analysis of differentially expressing microRNAs among CTCL cell-line-derived exosomes using Affymetrix microRNA microarray. (b) Reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) analysis of differential expression of miR-155, miR-1246 and nonrelevant miR-199 normalized to U6 in exosomes of CTCL cell lines, presented as relative quantification (RQ), where MJ exosomal microRNA has RQ = 1. (c–e) RT-qPCR analysis of miR-155 and miR-1246 expression in MyLa, Hut78 and HH cell lines with vs. without the addition of MJ exosomes (24 h) (c); and in normal peripheral blood mononuclear cells (NPBMCs) with and without addition of MyLa and MJ exosomes (24 h) for miR-155 (d) and for miR-1246 (e) normalized to U6, presented as the RQ, where cells without exosomes have RQ = 1.