Table 2.

Case study summary

Domain	Low adherence (addressed < 19 recommendations)		High adherence (addressed ≥ 19 recommendations)
	McGrath, 2013	Al-Omran, 2014	McAlindon, 2017	Chevalier, 2010
Randomization (max. ✓)			✓	✓
Blocking/stratification (max. ✓)	✓	✓	✓	✓
Blinding (max. ✓✓✓)	✓	✓	✓✓✓	✓✓✓
Expectations (max. ✓)
Washout periods/concomitant medications (max. ✓)	✓	✓	✓	✓
Outcome reporting training (max. ✓)	✓	✓	✓	✓
Comorbidities/ subphenotypes (max. ✓✓)	✓✓	✓✓	✓✓	✓✓
Characterizing baseline disease (max. ✓)			✓	✓
Selecting an index knee (max. ✓)	✓		✓
Symptom-modifying interventions (max. ✓)			✓	✓
Structure-modifying interventions (max. ✓)	✓	✓	✓	✓
Trial interventions (max. ✓)			✓	✓
Trial outcome measures (max. ✓✓)	✓	✓✓	✓✓	✓✓
Patient-reported outcome measures (max. ✓)	✓		✓	✓
Objective outcome measures (max. ✓)	✓		✓
Structural outcome measures (max. ✓✓✓)	✓	✓	✓✓✓	✓
Biochemical biomarkers (max. ✓)			✓
Reporting (max. ✓✓)		✓	✓✓	✓✓
Total number of addressed recommendations	12	11	24	19

✓ = Recommendation was adequately addressed in the trial publication or was not applicable