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. 2022 Feb 22;20:91. doi: 10.1186/s12951-022-01290-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — A D_h and PDI of PHEMA-g- (PCL-BM: CD-star-PMAA-b-PNIPAM) micellar solutions at various weight ratios of BM moieties to β-CD. The ultimate polymer concentration of each sample was set at 0.2 mg/ml. B Intensity ratio I₃₈₄/I₃₇₃ from pyrene excitation as a function of the concentration of the PHEMA-g-(PCL-BM: CD-star-PMAA-b-PNIPAM) micelles. C 2D-NOESY NMR spectra of the PHEMA-g-(PCL-BM: CD-star-PMAA-b-PNIPAM) inclusion complex in DMSO-d6 as solvent at a guest/host weight ratio of 1:3 (400 MHz). D FTIR spectra of PHEMA-g-(PCL-BM) (guest), CD-star-PMAA-b-PNIPAM (Host), and PHEMA-g-(PCL-BM): CD-star-PMAA-b-PNIPAM (micelle). E Fluorescence emission spectra of PHEMA-g-(PCL-BM) in DMSO/PBS solutions with different CD-star-PMAA-b-PNIPAM concentrations (λ_ex = 297 nm). F 3D and 2D atomic force microscopy (AFM) images of PHEMA-g-(PCL-BM), G PHEMA-g-(PCL-BM: CD-star-PMAA-b-PNIPAM) inclusion complex