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. 2022 Feb 22;23:76. doi: 10.1186/s12882-022-02704-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a Bacteroidetes and Synergistetes were significantly increased in the EP group at the phylum level (p < 0.05) (b). Bacillales and Lactobacillales were significantly decreased in the EP group at the order level (p < 0.05). c Phenotype prediction showed that Gram-negative status was significantly increased in the EP group (P = 0.013). d Phenotype prediction showed that the Gram-positive status was significantly decreased in the EP group (P = 0.013). e The KEGG pathway analysis of the second level was compared with metabolic analysis between the EP group and the NG. (1). For the left half of the graph, the Y axis represents the KEGG pathways of levels. The length of the column indicates the KO abundance in the pathway. (2). For the right half of the graph, the X axis represents the confidence interval of the difference in species abundance, and the Y axis represents the P value. KEGG: Kyoto encyclopedia of genes and genomes