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. 2022 Feb 23;21:60. doi: 10.1186/s12943-021-01447-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — METTL3 knockdown enhances antitumor immunity and immune infiltration. a Bioluminescent images of intraperitoneal xenografted tumors from the indicated groups for Day 12 and Day 24. b The CD3⁺, CD4⁺ and CD8⁺ densities and PD-L1 expression were determined by Immunohistochemical analysis in the intraperitoneal xenografted tumors. Scale bar, 20 μm. c Images of subcutaneous tumors from the indicated groups (scale bar: 1 cm). d The CD3+, CD4+ and CD8+ densities and PD-L1 expression were determined by Immunohistochemical assay in the subcutaneous xenograft models. Scale bar, 20 μm