Comparison 2. Quality of Life.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Patient Global	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 Mild to Moderate SLE	2	148	Mean Difference (IV, Fixed, 95% CI)	‐11.46 [‐19.08, ‐3.84]
1.2 Severe SLE	1	19	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐3.67, 3.27]
2 Physician Global	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Mild to moderate SLE	2	148	Mean Difference (IV, Fixed, 95% CI)	‐3.16 [‐8.12, 1.80]
2.2 Severe SLE	1	19	Mean Difference (IV, Fixed, 95% CI)	‐9.80 [‐40.36, 20.76]