Table 1.
Evaluation of genes associated with caspofungin resistance
| Gene symbol | Systematic name | Mutations found | Mutation in resistant isolates (1875–1256) | Resistance-associated mutation (+/−) |
|---|---|---|---|---|
| CEK1 | CAGL0K04169g | – | – | − |
| CDC55 | CAGL0L06182g | – | – | − |
| CDC6 | CAGL0K00605g | R117K, V163A, K268R, R80K | – | − |
| DOT6 | CAGL0I05060g | P104S | – | − |
| FKS1 | CAGL0G01034g | G14S | – | − |
| FKS2 | CAGL0K04037g | F659-Del, T926P | F659-Del | + |
| FKS3 | CAGL0M13827g | A42V, T1676S | – | − |
| MKT1 | CAGL0J05566g | N512K, A643T | – | − |
| MOH1 | CAGL0F04631g | S15N | – | − |
| MPH1 | CAGL0F04895g | – | – | − |
| MRPL11 | CAGL0J09724g | – | – | − |
| MSH2 | CAGL0I07733g | – | – | − |
| PDR1 | CAGL0A00451g | V91I, L98S, D243N | – | − |
| PHO4 | CAGL0D05170g | S327N | – | − |
| SNQ2 | CAGL0I04862g | P1104H | – | − |
| SUI2 | CAGL0B03795g | – | – | − |
| TCB1 | CAGL0J08591g | Q437E, K585R, N622K | – | − |
| TCB3 | CAGL0L11440g | – | – | − |
| TOD6 | CAGL0A04257g | P64S, D81N, N85D | – | − |
| TPK2 | CAGL0M08404g | T132A, T158A | – | − |
| CRZ1 a | CAGL0M06831g | – | – | − |
| SLT2 a | CAGL0J00539g | – | – | − |
| SRP1 a | CAGL0J11440g | – | – | − |
| DBP5 a | CAGL0L110021g | – | – | − |
| SWI1 a | CAGL0C01683g | – | – | − |
a
Genes encoding proteins related to the caspofungin exposure response found in this study.