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. 2022 Feb 18;60(1):467–478. doi: 10.1080/13880209.2022.2039216

Figure 3.

Figure 3.

Effect of FAEE on the expression of osteoclastogenesis-associated genes and proteins (A-I). FAEE inhibited RANKL-induced mRNA expression of TRAP (A), c-Src (B), Cathepsin K (C), Nuclear factor of activated T cells c1 (NFATc1) (D), Matrix metalloproteinase 9 (MMP-9) (E), The osteoclast-associated receptor (OSCAR) (F), Acp-5 (G), and Atp6v0d2 (H) in RAW 264.7 cells as determined by qRT-PCR. FAEE inhibited RANKL-induced protein expression of c-Fos, c-Src and NFATc1 (I) as determined by western blotting. Quantitative ratio of c-Fos (J), c-Src (K) and NFATc1 (L) to the band strength of β-Tubulin. Data are the mean ± SEM of triplicate experiments. ### p < 0.001 versus RAW 264.7 cells without RANKL, ** p < 0.01 and *** p < 0.001 versus RAW 264.7 cells with RANKL alone.