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A model for TEX264 function in the ER and nucleus. TEX264 is anchored at both the ER and inner nuclear membrane via its N-terminal single-pass transmembrane domain. TEX264 promotes degradation of portions of the ER during starvation by binding LC3-coated phagophores via its C-terminal LIR. At the inner nuclear membrane, TEX264 associates with VCP-SPRTN subcomplexes via its C-terminal SHP box and promotes TOP1cc repair.
