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. 2022 Feb 21;14(1):2035660. doi: 10.1080/19490976.2022.2035660

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Intestines of conventional and SPF mice show strongly divergent transcriptional profiles. RNA sequencing was performed on −80°C preserved tumor-free small intestines from tamoxifen-treated conventional or SPF Msh2-Lynch mice (n = 4). a, Heatmap depicting row z-scores of and b, Volcano plot, showing differentially expressed genes (P < .05, FC>1.5). c, IPA on differentially expressed genes between SPF and conventional mice. The top 10 significant pathways with positive or negative z-score are shown. d, GSEA analyses comparing transcriptional profiles of conventional and SPF mice to MSigDB Hallmark gene sets. Normalized enrichment score (NES) and false discovery rate (FDR) q-value are indicated.