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. 2022 Feb 21;14(1):2035660. doi: 10.1080/19490976.2022.2035660

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The conventional microbiota differentially impact tumorigenesis and mutagenesis in distinct CRC models. a, Number of lesions scored from HE stained small intestinal tissue sections of Lgr5-Cre;Apc^flox/flox mice after SPF or conventional FMT (n = 13). Neoplastic lesions up to a size of 100 µm were included in the analysis b, Number of colonic lesions. Plotted are mean and SD. Asterisks indicate a significance level of P < .05, P < .01, P < .001 and P < .0001, respectively (Student’s t-test). c, Survival after induction of Apc loss in SPF- or conventional-FMT-treated Lgr5-Cre;Apc^flox/flox mice (n = 13). d, Survival after 10d TMZ treatment of Msh2-Lynch mice that received SPF or conventional FMT or born as the first generation after conventional FMT. e, Distribution of the MSI score in small intestinal MSH2-deficient organoids derived from Msh2-Lynch mice after SPF (n = 4) or conventional (n = 5) FMT. Plotted are mean and SD. Asterisk indicates a significance level of P < .05 (Two-way ANOVA, with Sidak’s test for multiple comparisons).