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. 2022 Feb 18;11(1):2040772. doi: 10.1080/2162402X.2022.2040772

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Multiplexed single cell profile of activation, maturation, trafficking, and immune checkpoint of human T cells.

(A) Normalized (99.9th percentile) violin plots of all assessed proteins across T cells subsets. Black dots indicate population means. Bimodality indicated by arrows. *p < .05, **p < .01, ***p < .001 and ****p < .0005 indicate significant difference. (B) Normalized (99.9th percentile) median expression of all assessed proteins across T cell subsets. (C) Overlay of manually gated T cell subsets on optSNE embedding. Each color designates a subset ID. (D) Overlay of unsupervised clustering by FlowSOM of T cells on optSNE embedding. Each color designates a cluster ID. (E) Normalized (99.9th percentile) median expression of all assessed proteins across T cells for manually undefined clusters. TN = naïve T cells; TSCM = stem cell memory T cells; TCM = central memory T cells; TEFF = effector T cells; TEM = effector memory T cells; TEMRA = effector memory CD45RA+ T cells. Data are representative of three independent experiments.