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. 2021 Mar 29;17(2):202–219. doi: 10.1080/15592294.2021.1896983

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Chromatin accessibility analysis using cell type-specific ATAC-seq assay in post-mortem human brain. FRiP scores (a) and genomic peak distribution (b) of the ATAC-seq data generated from neuronal (NeuN+) nuclei of the two post-mortem human anterior cingulate cortices (Brodmann areas 24/32; Brains A and B). A/B IDR peaks, high confidence peaks generated by the IDR analysis, were then used for the GO Cellular component (c) and KEGG pathway (d) analyses. Colours indicate adjusted p values and dot size corresponds to gene count. Top 15 GO and top 10 KEGG pathways are shown. Motif analysis of the ATAC-seq data (e) shows top 25 transcription factor binding motifs. Colours indicate log adjusted P values and dot size corresponds to percent target.