Courteix 2005.

Methods	STUDY DESIGN: randomised controlled trial LOCATION AND SETTING: Community (school and sports clubs), France DURATION OF SUPPLEMENTATION: 1 year DURATION OF FOLLOW‐UP: 1 year QUALITY ASSESSMENT: low risk of bias RANDOMISED: random and description consistent with this ALLOCATION CONCEALMENT: Yes BLINDING OF SUBJECT: Yes DESCRIPTION OF WITHDRAWALS/DROPOUTS: Yes TYPE OF ANALYSIS: Available Data COMPLIANCE: Assessed CONFOUNDERS MEASURED: physical activity, pubertal status, spontaneous calcium intake
Participants	N SCREENED: 138 N RANDOMISED: 113 N COMPLETED: 85 (1 year) M=0% F=100% ETHNICITY: CAUCASIAN MEAN BASELINE AGE (yrs): 9.91 BASELINE AGE RANGE (yrs): 8‐13 INCLUSION CRITERIA: healthy Caucasian females, age 8‐13, prepubescent and not expected to reach menarche before end of first year of study EXCLUSION CRITERIA: children with swimming as a physical activity BASELINE CALCIUM INTAKE (mg/day): 994 PUBERTAL STAGE: prepubertal
Interventions	1. 800 mg/day calcium as calcium phosphate 2. Placebo CO‐INTERVENTIONS: Nil
Outcomes	BONE MEASURES: SITES AREAL BONE MINERAL DENSITY: total body, dominant hip (femoral neck, trochanter and Ward's triangle), non‐dominant radius (1/3, mid and distal) and L2‐4 vertebrae. BONE MINERAL CONTENT: total body, dominant hip (femoral neck, trochanter and Ward's triangle), non‐dominant radius (1/3, mid and distal) and L2‐4 vertebrae. METHOD OF MEASUREMENT: DXA FOLLOW‐UP ASSESSMENT POINTS(yrs): 0, 1 OTHER OUTCOMES MEASURED: BMI, height, bone age, fat mass, lean mass BONE MEASURES INCLUDED IN ANALYSES: AREAL BONE MINERAL DENSITY: total body, dominant hip (femoral neck, trochanter and Ward's triangle), non‐dominant radius (1/3, mid and distal) and L2‐4 vertebrae. BONE MINERAL CONTENT: total body, dominant hip (femoral neck, trochanter and Ward's triangle), non‐dominant radius (1/3, mid and distal) and L2‐4 vertebrae. SUB‐GROUPS IDENTIFIED: exercise (7.2 hours exercise per week) and sedentary (1.2 hours exercise per week)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate