Skip to main content
. Author manuscript; available in PMC: 2022 Dec 17.
Published in final edited form as: ACS Catal. 2021 Nov 30;11(24):14956–14966. doi: 10.1021/acscatal.1c04520

Fig 5. 3-OST-5 products have varying anti-FXa activity.

Fig 5.

8-mer products of 3-OST-5 were assessed for anti-FXa activity in a standard chromogenic assay. Fondaparinux and a non-anticoagulant 6-mer lacking 3-O-sulfation were used as positive and negative controls respectively. The antithrombin (AT) pentasaccharide binding sequence in 8-mers 6, 8, and 9 is boxed. These three 8-mers display strong anti-FXa activity. 8-mers 4 and 5 had minimal anti-FXa activity, consistent with their lack of the AT-binding pentasaccharide. Shorthand structures for 8-mers and non-anticoagulant 6-mer used in the analysis are shown at the bottom of the figure.