TABLE 1.
Demographic and clinical characteristics among participants receiving convalescent plasma and controls
| Characteristic | Convalescent plasma (N = 29) | Controls (N = 48) | P-value |
|---|---|---|---|
| Age yr, median (Q1, Q3) | 61.1 (51.7, 66.9) | 65.3 (49.2, 78.4) | 0.131 |
| Sex, female (%) | 14 (48.3) | 30 (62.5) | 0.24 |
| Race/ethnicity | |||
| White Non-Hispanic (%) Hispanic (%) Black (%) Asian American Indian/Alaskan Native Other |
8 (27.6) 12 (41.4) 7 (24.1) 0 0 2 (6.9) |
10 (20.8) 14 (29.2) 22 (45.8) 0 0 2 (4.1) |
0.26 |
| Diabetes | 12 (41.4) | 19 (39.6) | >0.99 |
| Hypertension | 17 (58.6) | 31 (64.6) | 0.63 |
| Asthma | 2 (6.9) | 5 (10.4) | 0.71 |
| COPD/emphysema | 3 (10.3) | 4 (8.3) | >0.99 |
| World Health Organization Ordinal scale at admissiona Category 3 (%) Category 4 (%) |
10 (34.5) 19 (65.5) |
18 (37.5) 30 (62.5) |
0.81 |
| Admission laboratory valuesb | |||
| Creatinine mg/dL, median (Q1, Q3) | 1.1 (0.7, 1.4) | 1.0 (0.7, 1.3) | 0.27 |
| White blood cell count k/μL, median (Q1, Q3) | 6.5 (4.9, 7.6) | 5.7 (4.5, 6.9) | 0.333 |
| Total lymphocyte count k/μL, median (Q1, Q3) | 0.8 (0.7, 1) | 0.9 (0.6, 1.4) | 0.54 |
| D-dimer ng/mL, median (Q1, Q3) | 322 (241, 604) | 301 (219, 454) | 0.46 |
| Ferritin ng/mL, median (Q1, Q3) | 522 (319, 1075) | 445 (257, 876) | 0.27 |
| C-reactive protein mg/dL, median (Q1, Q3) | 9 (4.8, 13.5) | 11.7 (3.6, 14.1) | 0.74 |
| BMI, median (Q1, Q3) | 32.9 (31.6, 41.8) | 33.6 (28.0, 37.6) | 0.551 |
| Days from first symptom onset to admission, median (Q1, Q3) | 5 (3, 7) | 5 (2, 8.5) | 0.54 |
aStudy enrolled only those with score 3 (hospitalized but no supplemental oxygen) and score 4 (hospitalized with oxygen by nasal prongs or mask but without high-flow or noninvasive ventilation).
bNormal laboratory values: Creatinine (available in all participants with convalescent plasma and controls) adult male 0.7–1.3 mg/dL and adult women 0.4–1.1 mg/dL; white blood cell count (available in all participants that received convalescent plasma and controls) 4.0-11.0 k/μL; absolute lymphocyte count 1.0–5.0 k/μL; d-dimer (available in 26 participants that received convalescent plasma and 39 controls) <243 ng/mL; Ferritin (available in 23 participants that received convalescent plasma and 37 controls) adult male 20–275 ng/mL and adult female 5–200 ng/mL; C-reactive protein (available in 23 participants that received convalescent plasma and 37 controls) <0.5 mg/dL. BMI control n = 42, BMI convalescent plasma n = 26.