TABLE 2.

Differential changes of T-cell epitope in type-I EBV among pLELC and healthy controls

Protein	Epitope sequence	Amino acid change	HLA Restriction	% in pLELCa	% in controlb	Or (95% CI)	P-valuec
LMP2	TYGPVFMCL	C426S	A24	0.96	0.68	11.48 (3.46, 38.07)	2.54 × 10−06
	CLGGLLTMV	C426S	A2.01	0.96	0.68	11.48 (3.46, 38.07)	2.54 × 10−06
	TYGPVFMCLGGLLTMVAGAV	C426S	DQB1*0601	0.96	0.68	11.48 (3.46, 38.07)	2.54 × 10−06
EBNA3A	YPLHEQHGM	H464R	B35.1	0.22	0.51	0.28 (0.15, 0.51)	7.72 × 10−05
	VQPPQLTLQV	V617E	B46	0.01	0.18	0.06 (0.01, 0.44)	1.80 × 10−04
	VQPPQLTLQV	P620T	B46	0.83	0.52	4.45 (2.29, 8.63)	2.14 × 10−05
EBNA3B	TYSAGIVQI	I225L	A24.02	0.00	0.16	/	7.72 × 10−05
	AVFDRKSDAK	A399S	A11	0.12	0.34	0.26 (0.12, 0.57)	8.74 × 10−04
	AVFDRKSDAK	V400F	A11	0.04	0.27	0.11 (0.03, 0.36)	4.87 × 10−05
	AVFDRKSDAK	D402N	A11	0.68	0.37	3.45 (1.97, 6.04)	5.91 × 10−05
	IVTDFSVIK	V417L	A11	0.14	0.47	0.19 (0.09, 0.38)	3.42 × 10−06
	IVTDFSVIK	K424N	A11	0.82	0.43	6.29 (3.17, 12.46)	4.49 × 10−07
	VEITPYKPTW	Y662D	B44	0.05	0.27	0.15 (0.05, 0.43)	7.72 × 10−05
	VEITPYKPTW	K663E	B44	0.08	0.32	0.17 (0.07, 0.42)	5.28 × 10−05
	QAPTEYTRERRGVGPMPPT	A847E	DRB3*0201	0.14	0.39	0.26 (0.13, 0.52)	1.72 × 10−05
EBNA3C	ILCFVMAARQRLQDI	I141V	DR13	0.82	0.59	3.05 (1.60, 5.84)	1.12 × 10−05
	QNGALAINTF	Q213H	B62	0.79	0.48	4.06 (2.19, 7.55)	2.14 × 10−05
	KEHVIQNAF	E336D	B44.2	0.81	0.52	3.88 (2.06, 7.30)	5.28 × 10−05
	PQCFWEMRAGREITQ	R656G		0.83	0.54	4.15 (2.09, 8.25)	7.72 × 10−05
BZLF1	LLQHYREVAA	A205S		0.77	0.49	3.38 (1.86, 6.16)	9.52 × 10−05
	RKCCRAKFKQLLQHYR	Q195H	C6	0.77	0.49	3.38 (1.86, 6.16)	9.52 × 10−05
	RAKFKQLL	Q195H	B8	0.77	0.49	3.38 (1.86, 6.16)	9.52 × 10−05
	TVQTAAAVVF	F130L		0.75	0.47	3.43 (1.90, 6.19)	7.72 × 10−05
	PGDNSTVQTAAAVVF	F130L	DRB1*13	0.75	0.47	3.43 (1.90, 6.19)	7.72 × 10−05
	PGDNSTVQTAAAVVF	A125del	DRB1*13	0.25	0.52	0.30 (0.17, 0.54)	9.52 × 10−05
	LQHYREVAA	Q105L	C8	0.75	0.47	3.43 (1.90, 6.19)	7.72 × 10−05
	VSTAPTGSWF	T68A	B58.01	0.75	0.48	3.35 (1.86, 6.06)	9.52 × 10−05
	LTAYHVSTAPTGSWF	T68A	DRB3*02	0.75	0.48	3.35 (1.86, 6.06)	9.52 × 10−05
BRLF1	VHEPVGSLTPAPV	V479I		0.05	0.24	0.17 (0.06, 0.50)	4.41 × 10−04
BLLF3	HLTSFYSPHSDAGVL	L235I		0.08	0.25	0.26 (0.16, 0.63)	2.43 × 10−03
BNRF1	PPGPSAVIEHLGSLV	G456R		0.01	0.29	0.04 (0.005, 0.26)	1.77 × 10−06
	GPGMQQFVSSYFLNP	S497G		0.01	0.24	0.04 (0.005, 0.30)	5.54 × 10−06

^aFrequency of risk alleles in pLELC patients.

^bFrequency of risk alleles in healthy controls.

^cP-value was calculated using Fisher's exact test and adjusted by false discovery rate.

Abbreviations: OR, odds ratio; CI, confidence interval.