FIG 4.

c19s130Fc limits SARS-CoV-2-mediated CPE on Vero cells. Vero cells were treated with the indicated concentrations of c19s130Fc, VHH72Fc, and cs130Fc and infected afterward with SARS-CoV-2 at an MOI of 0.03. (A) Bright-field images were taken on day 3 postinfection (one representative out of 4 is shown) (bar = 1 mm). (B to D) CPE scores and TOX scores of c19s130Fc (B), VHH72Fc (C), and cs130Fc (D) were determined from bright-field images from panel A by CPETOXnet and are shown in a concentration-dependent manner (n = 4). (E) CPE scores (left) and TOX scores (right) of the negative, positive, and toxic controls calculated by CPETOXnet on images 3 days after infection at an MOI of 0.03 or with staurosporine (5 μM)-treated cells.