FIG 2.

Best change in tumor diameter according to PIK3CA mutation domain and comutations. Investigator-assessed best change in tumor diameter is shown. Patients are grouped by PIK3CA mutation type (top). Co-occurring mutations or CNVs are shown and color-coded by variant type (middle). Comutations categorized by pathway, best overall response, and tumor histology are indicated (bottom). Adeno, adenocarcinoma; CNV, copy-number variant; Gyne. endo., endometrial carcinoma; Gyne ovary, ovarian carcinoma; HNSCC, head and neck squamous cell carcinoma; Indel, insertion or deletion; PD, progressive disease; RTK, receptor tyrosine kinase; SCC Anog., squamous cell carcinoma of the anogenital region; SD, stable disease; SNV, single-nucleotide variant; UE or Uneval, unevaluable; UGI, upper GI.