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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Addict Biol. 2021 Jun 10;26(5):e13051. doi: 10.1111/adb.13051

Figure 3. Prefrontal PICK1 knockdown leads to sex-specific effects on cue-induced reinstatement of cocaine seeking.

Figure 3.

Male and female mice showed no effect of prefrontal PICK1 knockdown (KD) on the time to reach extinction criterion (A). However, PICK1 KD in the mPFC of male mice led to a significant decrease in active responses during cue-induced reinstatement [B, F(1,20)= 4.44, *p<0.01, n=10–12/group]. In contrast, PICK1 KD in the mPFC of female mice led to an increase in active responses during cue-induced reinstatement [C, interaction: F(1,19)= 4.87, *p<0.01, n=9–13/group].