Fig 5.

Estimation on the number of people with a cumulative number of risk alleles in the world major populations for a) susceptibility for COVID-19 infection (rs286914 + rs12329760) and b) severe COVID-19 with respiratory failure (rs657152 + rs11385942). 0 to 4 represents the sum of effect alleles for each COVID-19 associated phenotype. Data for the Portuguese(n = 623), Spanish (n = 9761) and Italian (6363) populations correspond to observed values extrapolated to 1 million, whereas data for major world populations correspond to estimations (also to 1 million) based on the published effect allele frequencies, after Hardy-Weinberg equilibrium validation. Allele frequencies for rs286914, rs12329760 and rs11385942 were obtained from gnomAD-Genome project, while rs657152 allele frequencies were obtained from the ALFA project. All populations’ distributions were compared with the European distribution. ✝ - population used as reference for statistical analyses. ***: p-value<0.0001. NA—No data available.