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. 2022 Feb 9;10:832059. doi: 10.3389/fbioe.2022.832059

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Copyright © 2022 Nupur, Joshi, Gulliarme and Rathore.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RP-LC-MS based primary structure biosimilarity assessment of trastuzumab originator and biosimilars as adapted from Joshi and Rathore, 2020. (A) mirror plot of Intact profile, (B) mirror plot of reduced profile and (C) stacked chromatograms of trastuzumab biosimilars compared with originator.