TABLE 1.
Characteristics of Cases Identified in FAERS Database (n = 491)
| Characteristics | Canagliflozin, n | Dapagliflozin, n | Empagliflozin, n | Ertugliflozin, n | Total, n (%) |
|---|---|---|---|---|---|
| Number of cases | 162 | 101 | 223 | 5 | 491 (100) |
| Sex Male Female Not specified |
121 35 6 |
20 77 4 |
145 55 23 |
5 0 0 |
291 (59) 167 (34) 33 (7) |
| Age, years 20–29 30–39 40–49 50–59 60–69 70–79 80–89 Not specified |
0 12 38 45 38 12 0 17 |
1 7 13 24 21 5 0 30 |
0 6 19 49 55 19 6 69 |
0 0 1 2 0 0 0 2 |
1 (<1) 25 (5) 71 (14) 120 (24) 114 (23) 36 (7) 6 (1) 118 (24) |
| Outcomes Hospitalized Died Not specified |
109 5 48 |
26 4 71 |
143 12 68 |
4 — 1 |
282 (57) 21 (4) 188 (38) |
| Concomitant antihyperglycemics Biguanides Sulfonylureas Incretin mimetics DPP-4 inhibitors Pioglitazone Insulin Combination* None Not reported |
5 0 1 0 1 2 6 2 145 |
10 1 0 1 0 7 28 6 48 |
11 0 1 1 0 13 71 8 117 |
0 0 0 0 0 1 1 0 3 |
26 (5) 1 (<1) 2 (<1) 2 (<1) 1 (<1) 23 (5) 106 (22) 16 (3) 314 (64) |
*
Combination indicates more than one antihyperglycemic agent was used in combination with the reported SGLT2 inhibitor.