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. 2022 Jan 13;11:e70382. doi: 10.7554/eLife.70382

Figure 2. Distribution of automatic mitochondrial copy (AutoMitoC) estimates and the influence of blood cell counts.

Figure 2.

(A) Histogram illustrating AutoMitoC mitochondrial DNA copy number (mtDNA-CN) estimates in 395,781 UKBiobank participants expressed per SD change in mtDNA-CN. Associations between blood cell counts with mtDNA-CN levels as conveyed by forest plots illustrating effect estimates (left) and a bar plot showing the proportion of variance in mtDNA-CN explained (right). Models were adjusted for age, age2, sex array type, 20 genetic principal components, and ethnicity. Both blood cell counts and mtDNA-CN levels were standardized (mean = 0; SD = 1).

Figure 2—source data 1. Table showing the association of blood cell counts and AutoMitoC mtDNA-CN estimates in the UKBiobank.
Effect estimates (betas, 95% CI, p-values) are expressed in terms of change in mtDNA-CN per 1 SD increase in blood counts. The variance explained (r2) by blood cell counts is also provided.