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In vivo pharmacokinetics and biodistribution. (a) Time-dependent blood clearance of 89Zr-PD-1 IgG following intravenous injection into normal Balb/C mice. Curve fitting by two-phase decay shows biexponential blood clearance that derives pharmacokinetic parameters of early and late rate constants (K1 and K2) and half-lives (T1/2α and T1/2β). (b) Biodistribution of 89Zr-PD-1 IgG in normal Balb/C mice at 5 days after intravenous injection.
