Table 1.
Multiple Linear Regression Analyses of the Relationship Between BCAAs and SOD(A) or MDA(B) in Different Glucose Metabolism Groups
| A Independent Variable | Total (n=816) | NGM (n = 380) | Prediabetes (n = 334) | NDM (n = 102) | ||||
|---|---|---|---|---|---|---|---|---|
| β ± SE | P value | β ± SE | P value | β ± SE | P value | β ± SE | P value | |
| Model 1 | ||||||||
| BCAAs | −0.028 ± 0.03 | 0.369 | −0.012± 0.05 | 0.841 | 0.051 ± 0.059 | 0.388 | −3.639 ± 1.152 | 0.001 |
| L-Leu | −0.089 ± 0.074 | 0.232 | −0.05 ± 0.123 | 0.684 | −0.111 ± 0.136 | 0.415 | −0.643 ± 0.249 | 0.040 |
| L-Ile | −0.214 ± 0.141 | 0.129 | −0.139 ± 0.216 | 0.520 | −0.214 ± 0.260 | 0.411 | −1.023 ± 0.512 | 0.048 |
| L-Val | −0.009 ± 0.065 | 0.895 | −0.017 ± 0.104 | 0.871 | −0.087 ± 0.126 | 0.491 | −0.437 ± 0.230 | 0.030 |
| Model 2 | ||||||||
| BCAAs | 0.014 ± 0.034 | 0.667 | 0.023 ± 0.052 | 0.213 | 0.101 ± 0.064 | 0.119 | −3.312 ± 1.359 | 0.016 |
| L-Leu | 0.002 ± 0.079 | 0.992 | 0.064 ± 0.134 | 0.926 | 0.074 ± 0.126 | 0.921 | −0.575± 0.270 | 0.076 |
| L-Ile | 0.059 ± 0.151 | 0.694 | −0.038 ± 0.227 | 0.896 | 0.413 ± 0.281 | 0.142 | −0.473 ± 0.292 | 0.102 |
| L-Val | 0.075 ± 0.070 | 0.285 | 0.064 ± 0.134 | 0.457 | 0.181 ± 0.136 | 0.147 | −0.505 ± 0.262 | 0.036 |
| B Independent variable | Total (n=816) | NGM (n = 380) | Prediabetes (n = 334) | NDM (n = 102) | ||||
| β ± SE | P value | β ± SE | P value | β ± SE | P value | β ± SE | P value | |
| Model 1 | ||||||||
| BCAAs | 0.028 ± 0.03 | 0.369 | 0.100 ± 0.033 | 0.001 | 0.045 ± 0.023 | 0.027 | 0.036 ± 0.024 | 0.381 |
| L-Leu | 0.089 ± 0.074 | 0.232 | 0.005 ± 0.007 | 0.440 | 0.005 ± 0.004 | 0.344 | 0.005 ± 0.004 | 0.286 |
| L-Ile | 0.214 ± 0.141 | 0.129 | −0.009 ± 0.016 | 0.998 | 0.003 ± 0.004 | 0.702 | 0.019 ± 0.009 | 0.427 |
| L-Val | 0.020 ± 0.003 | <0.001 | 0.023 ± 0.06 | < 0.001 | 0.017 ± 0.006 | < 0.001 | 0.017 ± 0.04 | 0.040 |
| Model 2 | ||||||||
| BCAAs | 0.004 ± 0.001 | <0.001 | 0.008 ± 0.003 | 0.054 | 0.006 ± 0.002 | 0.010 | −0.006 ± 0.002 | 0.295 |
| L-Leu | 0.014 ± 0.005 | 0.124 | 0.007 ± 0.120 | 0.926 | 0.008 ± 0.112 | 0.234 | 0.003 ± 0.007 | 0.698 |
| L-Ile | 0.007 ± 0.006 | 0.248 | 0.004 ± 0.013 | 0.770 | 0.008 ± 0.010 | 0.436 | 0.019 ± 0.010 | 0.325 |
| L-Val | 0.022 ± 0.004 | <0.001 | 0.024 ± 0.006 | 0.001 | 0.020 ± 0.005 | <0.001 | 0.024 ± 0.009 | 0.022 |
Notes: Model 1: adjusted for age, gender and body mass index; Model 2: adjusted for age, gender, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, Ln (triglyceride), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum uric acid, smoking status and hypertension. The bold format serves as an emphasis note. Values were regression coefficient (β) ± standard error (SE). Definitions of NGM (normal glucose metabolism), prediabetes and T2DM (Type 2 diabetes) were in methods.
Abbreviations: BCAAs, branched-chain amino acids; SOD, superoxide dismutase.