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. 2022 Feb 19;16:435–466. doi: 10.2147/DDDT.S330947

Figure 14.

Figure 14

The effect of SX on the rat’s serum levels of IL-2, TNF-α, VEGF-A and IL-6 (Mean ± SEM, n = 10). (A) IL-2: *Compared to the Nor group, *P<0.05, (Mod group vs Nor group, *P=0.0215); #Compared to the Mod group, #P<0.05, ##P<0.01 (GTW group vs Mod group, #P=0.029; SX 40g/kg group vs Mod group, #P=0.021); ▲Compared to the GTW group, ▲P<0.05 (Mod group vs GTW group, ▲P=0.0298;SX 10g/kg group vs GTW group, ▲P= 0.0381). (B) TNF-α: *Compared to the Nor group, **P<0.01,(Mod group vs Nor group,**P=0.0064); #Compared to the Mod group, #P<0.05, ##P<0.01 (GTW group vs Mod group, #P=0.0346;SX 40g/kg group vs Mod group, #P= 0.0275, SX 20g/kg group vs Mod group, #P=0.0167); ▲Compared to the GTW group, ▲P<0.05 (Mod group vs GTW group, ▲P=0.0273; SX 10g/kg group vs GTW group, ▲P=0.0219). (C) VEGF-A: *Compared to the Nor group, **P<0.01, (Mod group vs Nor group,**P=0.0024); #Compared to the Mod group, #P<0.05, ##P<0.01 (GTW group vs Mod group, ##P=0.0062;SX 40g/kg group vs Mod group, ##P=0.0039, SX 20g/kg group vs Mod group, #P=0.0273); ▲Compared to the GTW group, ▲P<0.05 (Mod group vs GTW group, ▲P=0.0124;SX 10g/kg group vs GTW group, ▲P=0.0318). (D) IL-6: *Compared to the Nor group, **P<0.01,(Mod group vs Nor group, **P=0.0078); #Compared to the Mod group, #P<0.05, ##P<0.01 (GTW group vs Mod group, ##P=0.0043;SX 40g/kg group vs Mod group, ##P=0.0059, SX 20g/kg group vs Mod group, #P=0.0357); ▲Compared to the GTW group, ▲P<0.05 (Mod group vs GTW group, ▲P=0.0415; SX 10g/kg group vs GTW group, ▲P=0.0371).

Abbreviations: CIA, collagen-induced arthritis; GTW, Tripterygium wilfordii polyglycoside tablet; SX, Sidaxue.