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. 2022 Feb 19;16:435–466. doi: 10.2147/DDDT.S330947

Figure 15.

Figure 15

The effect of SX on the mRNA levels of NF-κBp65, STAT1, PTGS2, PI3K, AKT and VEGF-A in the rat’s joint synovial tissue (Mean ± SEM, n = 10). (A) NF-κBp65: *Compared to the Nor group, **P<0.01 (Mod group vs Nor group, **P=0.0064); #Compared to the Mod group, #P<0.05, ##P<0.01 (SX 40g/kg group vs Mod group, #P=0.026; SX 20g/kg group vs Mod group, #P=0.023; GTW group vs Mod group, ##P=0.0076); ▲Compared to the GTW group, ▲▲P<0.01 (Mod group vs GTW group, ▲▲P=0.0058; SX 10g/kg group vs GTW group, ▲▲P=0.0072). (B) STAT1: *Compared to the Nor group, **P<0.01 (Mod group vs Nor group, **P=0.0018); #Compared to the Mod group, #P<0.05, ##P<0.01 (SX 20g/kg group vs Mod group, #P=0.031; GTW group vs Mod group, ##P=0.0085; SX 40g/kg group vs Mod group, ##P=0.0038); ▲Compared to the GTW group,▲P<0.05, ▲▲P<0.01 (SX 20g/kg group vs GTW group, ▲P=0.041; Mod group vs GTW group, ▲▲P=0.0089;SX 10g/kg group vs GTW group, ▲▲P= 0.0068). (C) PTGS2: *Compared to the Nor group, **P<0.01 (Mod group vs Nor group, **P=0.0081); #Compared to the Mod group, #P<0.05, ##P<0.01 (SX 40g/kg group vs Mod group, #P=0.036; GTW group vs Mod group, ##P=0.0067); ▲Compared to the GTW group, ▲P<0.05, ▲▲P<0.01 (SX 20g/kg group vs GTW group, ▲P=0.023; Mod group vs GTW group, ▲▲P=0.0049; SX 10g/kg group vs GTW group, ▲▲P= 0.0037). (D) PI3K: *Compared to the Nor group, **P<0.01 (Mod group vs Nor group, **P=0.0074); #Compared to the Mod group, #P<0.05, ##P<0.01 (SX 20g/kg group vs Mod group, #P=0.024; GTW group vs Mod group, ##P=0.0088; SX40g/kg vs Mod, ##P=0.0049); ▲Compared to the GTW group, ▲P<0.05, ▲▲P<0.01 (SX 10g/kg group vs GTW group, ▲P=0.031; Mod vs GTW, ▲▲P=0.0073). (E) AKT: *Compared to the Nor group, **P<0.01 (Mod group vs Nor group, **P=0.0091); #Compared to the Mod group, #P<0.05, ##P<0.01 (SX 20g/kg group vs Mod group, #P=0.0042; GTW group vs Mod group, ##P=0.0095; SX 40g/kg group vs Mod group, ##P=0.0056); ▲Compared to the GTW group, ▲P<0.05, ▲▲P<0.01 (SX 20g/kg group vs GTW group, ▲P=0.0431; Mod group vs GTW group, ▲▲P=0.0072; SX 10g/kg group vs GTW group, ▲▲P=0.0075). (F) VEGF-A: *Compared to the Nor group, **P<0.01 (Mod group vs Nor group, **P=0.0093); #Compared to the Mod group, #P<0.05, ##P<0.01 (SX 40g/kg group vs Mod group, #P=0.039; SX 20g/kg group vs Mod group, #P= 0.028; GTW group vs Mod group, ##P= 0.0075; SX 10g/kg group vs Mod group, #P=0.039; SX 10g/kg group vs Mod group, #P=0.028); ▲Compared to the GTW group, ▲P<0.05, ▲▲P<0.01 (SX 10g/kg group vs GTW group, ▲P=0.019; Mod group vs GTW group, ▲▲P=0.0035).

Abbreviations: CIA, collagen-induced arthritis; GTW, Tripterygium wilfordii polyglycoside tablet; SX, Sidaxue.