Table 3.

Key Nodes and Topological Parameters of the PPI Network

Gene	Degree	Betweenness Centrality	Closeness Centrality
TNF	38	0.25	0.84
IL-6	34	0.14	0.77
VEGF	34	0.18	0.78
IL-8	28	0.08	0.70
PTGS2	23	0.04	0.65
IL-2	20	0.03	0.62

Abbreviation: PPI, protein-protein interaction.