Table 4.
Top Network Topology Parameters of the Interaction Network Between SX Herbal Medicines, Active Compounds and RA-Associated Targets
| Name | Degree | Betweenness Centrality | Closeness Centrality |
|---|---|---|---|
| JXT | 14 | 0.03 | 0.41 |
| FLZXGP | 11 | 0.02 | 0.35 |
| DXT | 4 | 0.00 | 0.32 |
| HGT | 3 | 0.00 | 0.26 |
| MOL000358 | 69 | 0.18 | 0.43 |
| MOL002565 | 58 | 0.16 | 0.41 |
| MOL000469 | 56 | 0.13 | 0.41 |
| MOL002663 | 56 | 0.14 | 0.41 |
| MOL000392 | 52 | 0.08 | 0.41 |
| MOL000497 | 50 | 0.13 | 0.40 |
| MOL010801 | 48 | 0.12 | 0.37 |
| MOL000502 | 46 | 0.07 | 0.40 |
| MOL000417 | 46 | 0.07 | 0.40 |
| MOL006504 | 44 | 0.08 | 0.37 |
| PTGS1 | 16 | 0.04 | 0.46 |
| ESR1 | 12 | 0.02 | 0.43 |
| CA2 | 12 | 0.02 | 0.43 |
| PTPN1 | 11 | 0.08 | 0.45 |
| CYP19A1 | 11 | 0.03 | 0.45 |
| ESR2 | 10 | 0.01 | 0.42 |
| CA12 | 10 | 0.01 | 0.42 |
| ABCB1 | 10 | 0.02 | 0.43 |
| CA1 | 10 | 0.01 | 0.42 |
| CA7 | 9 | 0.01 | 0.38 |
Notes: The table is arranged according to herbs, compounds, and targets. The higher the degree value, the more important it is.
Abbreviations: SX, Sidaxue; RA, Rheumatoid arthritis; JXT, ji-xue-teng; FLZXGP, fei-long-zhang-xue-geng-pi; DXT, da-xue-teng; HGT, hei-gu-teng.