Table 6.
Effect of SX on Joint Swelling in CIA Rats (Mean ± SEM, n = 10)
| Group | 7d | 14 d | 23 d | 30 d | 37 d |
|---|---|---|---|---|---|
| Nor group | 1.199±0.060 | 1.241 ± 0.082 | 1.306 ± 0.067 | 1.341 ± 0.063 | 1.400 ± 0.092 |
| Mod group | 1.171±0.075 | 1.616± 0.085*** | 1.621 ± 0.051*** | 1.645 ± 0.073*** | 1.666 ± 0.077** |
| GTW group | 1.216±0.074 | 1.549 ± 0.070*** | 1.404 ± 0.080**### | 1.353 ± 0.069### | 1.390 ± 0.085### |
| SX 40 g/kg group | 1.169±0.049 | 1.554 ± 0.088*** | 1.432 ± 0.070**### | 1.345± 0.065### | 1.416 ± 0.200## |
| SX 20 g/kg group | 1.203±0.057 | 1.600 ± 0.029*** | 1.543 ± 0.064***# | 1.484 ± 0.034***###▲ | 1.419 ± 0.102##▲▲ |
| SX 10 g/kg group | 1.178±0.062 | 1.590 ± 0.060*** | 1.578± 0.091***▲▲ | 1.541± 0.065***##▲▲▲ | 1.519 ± 0.236#▲▲▲ |
Notes: 14d: *Comparison with Nor group, ***P<0.001(Mod vs Nor, ***P=0.000; GTW vs Nor, ***P=0.000; SX 40 g/kg vs Nor, ***P=0.000; SX 20 g/kg vs Nor, ***P=0.000; SX 10 g/kg vs Nor, ***P=0.000); 23d: *Comparison with Nor group, **P<0.01, **P<0.001 (Mod vs Nor, ***P=0.000; GTW vs Nor, **P=0.009; SX 40 g/kg vs Nor, **P=0.001; SX 20 g/kg vs Nor, ***P=0.000; SX 10 g/kg vs Nor, ***P=0.000); #Compared with Mod group, #P<0.05, ##P<0.01, ###P<0.001 (GTW vs Mod, ###P=0.000, SX 40g/kg vs Mod, ###P=0.000, SX 20g/kg vs Mod, #P= 0.03); ▲Compared to the GTW group, ▲▲P<0.01 (SX 10g/kg vs GTW, ▲▲P= 0.007). 30d: *Comparison with Nor group, ***P<0.001 (Mod vs Nor, ***P=0.000; SX 20 g/kg vs Nor, ***P=0.000; SX 10 g/kg vs Nor, ***P=0.000); #Compared with Mod group, ##P<0.01, ###P<0.001 (GTW vs Mod, ###P<0.001, SX 40g/kg vs Mod, ###P=0.000, SX 20g/kg vs Mod, ###P=0.000, SX 20g/kg vs Mod, ##P= 0.003); ▲Compared to the GTW group, ▲P<0.05, ▲▲P<0.01, ▲▲▲P<0.001 (SX 20g/kg vs GTW, ▲▲P= 0.026, SX 10g/kg vs GTW, ▲▲▲P<0.001). 37d: *Comparison with Nor group, **P<0.01 (Mod vs Nor, **P=0.001); #Compared with Mod group, #P<0.05, ##P<0.01, ###P<0.001 (GTW vs Mod, ###P=0.000, SX 40g/kg vs Mod, ##P=0.0014, SX 20g/kg vs Mod, ##P=0.002, SX 20g/kg vs Mod, #P= 0.049); ▲Compared to the GTW group, ▲P<0.05, ▲▲P<0.01, ▲▲▲P<0.001 (SX 20g/kg vs GTW, ▲▲P= 0.001, SX 10g/kg vs GTW, ▲▲▲P<0.001); Treatment started after 14d.
Abbreviations: SX, Sidaxue; CIA, collagen-induced arthritis; GTW, Tripterygium wilfordii polyglycoside tablet.