Table 7.
Effect of SX on the AI Score of CIA Rats (Mean ± SEM, n = 10)
| Group | 7 d | 14 d | 23 d | 30 d | 37 d |
|---|---|---|---|---|---|
| Nor group | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Mod group | 3.875 ± 0.354*** | 3.500 ± 0.535** | 3.750± 0.463*** | 3.500 ± 0.535*** | 3.625± 0.518*** |
| GTW group | 3.500 ± 0.535 | 3.500 ± 0.535 | 2.500 ± 0.535# | 1.250 ± 0.463## | 0.375 ± 0.518### |
| SX 40 g/kg group | 3.750± 0.463 | 3.625 ± 0.518 | 2.625 ± 0.518 | 1.500 ± 0.535# | 0.500 ± 0.535## |
| SX 20 g/kg group | 3.750± 0.463 | 3.500 ± 0.535 | 2.875 ± 0.641 | 1.875 ± 0.641 | 1.250 ± 0.463 |
| SX 10 g/kg group | 3.083 ± 1.456 | 3.625 ± 0.518 | 3.250 ± 0.623 | 2.625 ±0.518 | 1.875± 0.641 |
Notes: 7d: *Comparison with Nor group, ***P<0.001; 14d: *Comparison with Nor group, **P=0.005; 23d: *Comparison with Nor group, ***P<0.001; #Compared with Mod group, #P<0.05 (GTW vs Mod, #P=0.049); 30d: *Comparison with Nor group, ***P<0.001; #Compared with Mod group, #P<0.05, ##P<0.01 (GTW vs Mod, ##P=0.003, SX 40g/kg vs Mod, #P= 0.018); 37d: *Comparison with Nor group, ***P<0.001; #Compared with Mod group, ##P<0.01, ###P<0.001 (GTW vs Mod, ###P<0.001, SX 40g/kg vs Mod, ##P= 0.001); Treatment started after 14d.
Abbreviations: SX, Sidaxue; AI, arthritis index; CIA, collagen-induced arthritis; GTW, Tripterygium wilfordii polyglycoside tablet.