Table 8.
Serum Cytokine Levels in CIA Rats (Mean ± SEM, n = 10)
| Group | IL-2 Level (pg/mL) |
TNF-α Level (pg/mL) |
VEGF-A Level (pg/mL) |
IL-6 Level (pg/mL) |
|---|---|---|---|---|
| Nor group | 128.63±11.53 | 29.79±4.62 | 50.55 ± 8.62 | 31.84±5.67 |
| Mod group | 178.25±12.31*Δ | 61.84±6.76**Δ | 159.71 ± 5.69**Δ | 78.68±7.31**Δ |
| GTW group | 131.36±13.28# | 38.84±6.54# | 64.92 ± 5.60## | 41.23±8.13## |
| SX 40 g/kg group | 137.12±12.42# | 31.63±5.31# | 69.64 ± 8.26## | 32.15±5.63## |
| SX 20 g/kg group | 154.32±13.25# | 40.23±6.13# | 88.92 ± 10.83# | 39.16±5.89# |
| SX 10 g/kg group | 175.61±11.78Δ | 55.34±4.67Δ | 130.05 ± 12.20Δ | 56.31±5.43Δ |
Notes: Compared to the Nor group, (IL-2: *P=0.0215; TNF-α: **P=0.0064; VEGF-A: **P=0.0024; IL-6: **P=0.0078); Compared to the Mod group, (IL-2: #P=0.0324, 0.0412, 0.026; TNF-α: #P=0.0346, 0.0275, 0.0167; VEGF-A: ##P=0.0062, 0.0039, #P=0.0273; IL-6: ##P=0.0043, 0.0059, #P=0.0357); Compared to the GTW group, (IL-2: ▲P=0.0298, 0.0381; TNF-α: ▲P=0.0273, 0.0219; VEGF-A: ▲P=0.0124, 0.0318; IL-6: ▲P=0.0415, 0.0371).
Abbreviations: CIA, collagen-induced arthritis; GTW, Tripterygium wilfordii polyglycoside tablet; SX, Sidaxue.