Skip to main content
. Author manuscript; available in PMC: 2023 Feb 10.
Published in final edited form as: J Med Chem. 2022 Jan 26;65(3):2409–2433. doi: 10.1021/acs.jmedchem.1c01852

Scheme 3. β-Alanine Derivatives for Introduction of Distal H-Bonding Groups to Reach Polar and Charged Amino Acid Residues Adjacent to the CD73 Binding Sitea.

Scheme 3.

a Reagents and conditions: (i) β-alanine ethyl ester hydrochloride, HATU, DIPEA, DMF, 12 h, rt, ~100%; (ii) 1 N NaOH, MeOH, rt, 12 h, 92%; (iii) methylenebis(phosphonic dichloride), (CH3O)3PO, 0 °C, 3 h, 10%.