Table 1.

K_i Values of Compounds 10–31 and Archival Compounds 9, 75, and 76 in the Inhibition of Soluble hCD73 or as Otherwise Noted (triethylammonium salts were prepared and tested)^c

No.	Structure R1 = (other changes)	Ki ± SEM (nM, n=3)
9		10.6 ± 0.4a, 3.67 ± 0.26a,b
10		1.63 ± 0.28
11		1.58 ± 0.06
12		1.27 ± 0.18
13		0.894 ± 0.175
14		3.50 ± 0.11
15		1.14 ± 0.06
16		0.673 ± 0.091
17		0.441 ± 0.157
18		0.436 ± 0.078
19		1.08 ± 0.34
20		0.511 ± 0.041
21		0.848 ± 0.229
22		14.1 ± 2.9
23		1.76 ± 0.43
24		0.626 ± 0.076
25		1.78 ± 0.33
26		2.51 ± 0.51
27		2.61 ± 0.94 (n=2)
28	O	> 50 μM (28% inhibition)
29		59.2 ± 5.58
30		71.5 ± 17.6
31	O, R2 = F	2540 ± 710
75	O, R2 = CH3	338 ± 56a,b
76		4.58 ± 0.55a, 13.9 ± 1.6a,b

^aData from ref 28.

^bAt rat soluble CD73.²⁸

^cK_i is expressed as the mean of three independent determinations, each in duplicate, unless noted.