FIG 5.

Bbvac-induced antibodies confer some protection against infection with B. bronchiseptica and B. pertussis. Serum from mice that were naive (α-naïve), inoculated with B. bronchiseptica (α-BB), inoculated with B. pertussis (α-BP), vaccinated with Nobivac (α-Nobivac), vaccinated with Adacel (α-Adacel), or vaccinated with Bbvac (α-Bbvac) was transferred to naive C57BL/6J mice. Three hours later, mice were intranasally challenged with B. bronchiseptica (A) or B. pertussis (B), and mice were euthanized 7 days postinoculation to enumerate colonies in the respiratory tract. Two-way ANOVA, Dunnett's multiple-comparison test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Error bars represent standard error of the mean. n = 4 to 9 per strain and condition.