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. 2022 Feb 16;2022:8603427. doi: 10.1155/2022/8603427

Figure 2.

Figure 2

CPE-derived EVs deliver miR-155-5p to regulate neuronal injury. (a) The expression of miR-155-5p in CPE-derived EVs was measured by RT-qPCR. (b) The expressions of miR-155-5p in cocultured cell models after adding EVs were examined using RT-qPCR. (c) The transfection efficiency of miR-155-5p in CPE cells was quantified by RT-qPCR. (d) The expression of miR-155-5p in a cocultured cell model was determined by RT-qPCR. (e) The expression of autophagy-related proteins in the cell model after coculture was measured by western blot analysis. (f) The viability of neurons was measured by CCK-8 assay. (g) The number of TUNEL+ neurons was determined by TUNEL staining. ∗p < 0.05 vs. mimic-NC-transfected neurons, control- and EV-cotreated neurons, or EV- and mimic-NC-cotreated neurons. #p < 0.05 vs. inhibitor-NC-transfected neurons, OGD/R-PBS-treated neurons, or EV- and inhibitor-NC-cotreated neurons (n = 3).