Distribution of MICs of penicillin (a), tetracycline (b), ciprofloxacin (c), cefuroxime (d), spectinomycin (e), and ceftriaxone (f) for N. gonorrhoeae isolates. Symbols: , susceptible; , moderately susceptible or strains with reduced susceptibility; ▧, resistant. The breakpoint criteria used for assessing the susceptibility were those recommended previously (21, 22).